Description

2-Methyl-4-(Trifluoromethylthio)Phenol is a specialized fluorinated phenolic compound characterized by the presence of a trifluoromethylthio (-SCF₃) group. This unique structure imparts valuable properties such as enhanced lipophilicity and metabolic stability, making it a critical building block in advanced chemical synthesis. It is primarily utilized by research and development chemists and process engineers in the pharmaceutical and agrochemical industries. The compound serves as a key intermediate for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A versatile synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and anti-infective agents.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethylthio group can improve biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Acts as a precursor in the development of fluorinated components for electronic display materials, contributing to improved dielectric anisotropy and stability.
• Polymer Modification: Incorporated as a functional monomer to create specialty polymers with specific surface properties, chemical resistance, or tailored reactivity.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, nucleophilic aromatic substitution, and other transformations to introduce the -SCF₃ moiety into complex molecules.
• Research & Development: Serves as a standard or reference compound in analytical chemistry and material science research for method development and study of structure-activity relationships.

Basic Information

Product Name	2-Methyl-4-(Trifluoromethylthio)Phenol
CAS No.	709-96-6
Molecular Formula	C₈H₇F₃OS
Molecular Weight	208.20 g/mol
Synonyms	4-(Trifluoromethylthio)-2-methylphenol; 2-Methyl-4-(trifluoromethylthio)phenol; 2-Methyl-4-(trifluoromethylsulfanyl)phenol; 4-Hydroxy-3-methylphenyl trifluoromethyl sulfide; 3-Methyl-4-hydroxyphenyl trifluoromethyl sulfide; Phenol, 2-methyl-4-[(trifluoromethyl)thio]-; p-Hydroxy-m-tolyl trifluoromethyl sulfide
EINECS	Contact for details

Quality Control

Our production of 2-Methyl-4-(Trifluoromethylthio)Phenol adheres to stringent quality management protocols to ensure batch-to-batch consistency and purity for sensitive applications. Each lot is comprehensively analyzed using advanced techniques including GC, HPLC, and NMR spectroscopy. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as assay purity, identity confirmation, and impurity profiles. We support custom synthesis and can tailor specifications to meet specific research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber-colored or stored in dark conditions. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.