Description

5-Fluoroorotic Acid is a fluorinated derivative of orotic acid, a key intermediate in pyrimidine biosynthesis. This compound is of significant interest in biochemical research and pharmaceutical development due to its role as a selective inhibitor and a versatile building block for more complex molecules. It is primarily utilized by researchers and manufacturers in the life sciences sector, particularly in oncology research, enzyme studies, and the synthesis of novel nucleoside analogs.

Application

• Biochemical Research: Used as a selective inhibitor in studies of dihydroorotate dehydrogenase (DHODH) and other enzymes involved in pyrimidine metabolism.
• Pharmaceutical Intermediates: Serves as a critical precursor in the synthesis of fluorinated nucleosides and nucleotides with potential therapeutic applications.
• Oncology Research: Investigated for its role in disrupting cancer cell proliferation by interfering with DNA/RNA synthesis pathways.
• Microbiology Studies: Employed in microbial genetics and metabolic pathway analysis, particularly in yeast and other model organisms.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	5-Fluoroorotic Acid
CAS No.	703-95-7
Molecular Formula	C5H3FN2O4
Molecular Weight	174.09 g/mol
Synonyms	5-Fluoroorotic Acid; 5-Fluoro-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic Acid; 5-Fluorouracil-6-carboxylic Acid; 5-FOA; 5-Fluoroorotate; NSC 66985; 4-Carboxy-5-fluorouracil; 6-Carboxy-5-fluorouracil
EINECS	211-877-8

Quality Control

Our 5-Fluoroorotic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.