Description

Procyclidine is a synthetic anticholinergic agent belonging to the chemical class of piperidine derivatives. This compound is of significant commercial and pharmaceutical importance due to its specific pharmacological activity as a muscarinic acetylcholine receptor antagonist. It is primarily required by the pharmaceutical industry for the formulation of active pharmaceutical ingredients (APIs) used in the treatment of Parkinson's disease and drug-induced extrapyramidal symptoms.

Application

• Pharmaceutical Active Ingredient (API): Primary use in the formulation of medications for Parkinson's disease and related movement disorders.
• Neurological Research: Used as a reference standard and tool compound in preclinical studies investigating cholinergic pathways and receptor mechanisms.
• Drug Synthesis Intermediate: Serves as a key chemical building block in the synthesis of more complex therapeutic agents targeting the central nervous system.
• Quality Control & Analytical Standards: Employed as a high-purity certified reference material (CRM) for HPLC, GC, and spectroscopic assay development and validation in QC laboratories.

Basic Information

Product Name	Procyclidine
CAS No.	77-37-2
Molecular Formula	C19H29NO
Molecular Weight	287.44 g/mol
Synonyms	1-Cyclohexyl-1-phenyl-3-(1-pyrrolidinyl)-1-propanol; Kemadrin; Procyclidine Hydrochloride (salt form); Arpicolin; Osnervan; PMS-Procyclidine; Procyclidin; (RS)-1-Cyclohexyl-1-phenyl-3-(pyrrolidin-1-yl)propan-1-ol
EINECS	201-018-5

Quality Control

Our Procyclidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and potency, aligning with ICH guidelines and current Good Manufacturing Practices (cGMP). A detailed Certificate of Analysis (COA) is provided with every shipment, documenting results for assay, related substances, residual solvents, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.