Description

Thiopental Sodium CAS NO 71-73-8 is a rapid-onset, short-acting barbiturate derivative supplied as a hygroscopic powder. Its primary value lies in its potent anesthetic and sedative properties, making it a critical agent for the induction of general anesthesia. This product is essential for pharmaceutical manufacturers, research institutions, and compounding pharmacies involved in anesthetic and central nervous system depressant formulations. Consistent quality and reliable supply are paramount for ensuring predictable pharmacological activity and patient safety in medical applications.

Application

• General Anesthesia Induction: The primary and most significant application, used intravenously for the rapid induction of surgical anesthesia.
• Sedation in Intensive Care: Employed for long-term sedation of mechanically ventilated patients in critical care settings.
• Refractory Status Epilepticus: Used as a second or third-line agent to control seizures that do not respond to first-line treatments.
• Intracranial Pressure Reduction: Administered to lower elevated intracranial pressure in certain neurological emergencies.
• Veterinary Anesthesia: Utilized for the induction of anesthesia in various animal species in veterinary medicine.
• Pharmacological Research: Serves as a reference standard and active compound in neuroscience and anesthesiology research studies.

Basic Information

Product Name	Thiopental Sodium
CAS No.	71-73-8
Molecular Formula	C11H17N2NaO2S
Molecular Weight	264.32 g/mol
Synonyms	Thiopentone Sodium; Pentothal Sodium; 5-Ethyl-5-(1-methylbutyl)-2-thiobarbituric acid sodium salt; Sodium 5-ethyl-5-(1-methylbutyl)-2-thiobarbiturate; Sodium thiopental; Thiopentobarbital Sodium; Anesthal; Nesdonal; Trapanal; Intraval Sodium
EINECS	200-767-8

Quality Control

Our Thiopental Sodium is manufactured under strict quality systems. Each batch is tested to ensure it meets high-purity standards suitable for pharmaceutical applications. A comprehensive Certificate of Analysis (COA) is provided with every shipment, detailing key parameters such as assay, related substances, residual solvents, and microbiological quality. We support compliance with major pharmacopoeial standards, including USP and EP, upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term stability, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white, hygroscopic powder or cake
Identification (IR)	Conforms
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
pH (1% Solution)	10.5 - 11.5
Water (Karl Fischer)	≤ 2.0%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Bacterial Endotoxins	< 0.2 EU/mg
Sterility (if supplied sterile)	Sterile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.