Description

Digitoxin CAS NO 71-63-6 is a potent cardiac glycoside derived from the leaves of *Digitalis purpurea* (foxglove). This compound is a critical reference standard and active pharmaceutical ingredient (API) for the development and quality control of cardiovascular medications. It is essential for pharmaceutical manufacturers, research institutions, and analytical laboratories focused on cardiology and pharmacology.

Application

• Pharmaceutical Reference Standard: Primary use as a high-purity chemical standard for the identification, assay, and impurity profiling of digoxin and related cardiac glycosides in pharmacopeial testing (USP, EP).
• Active Pharmaceutical Ingredient (API): Serves as the core active component in the formulation of specific cardiac medications, though its clinical use is less common than digoxin.
• Biochemical Research: Used in pharmacological and toxicological studies to investigate the mechanism of action of cardiac glycosides on the Na⁺/K⁺-ATPase pump and myocardial contractility.
• Analytical Chemistry: Employed as a critical reagent in the development and validation of analytical methods, including HPLC, LC-MS, and immunoassays, for therapeutic drug monitoring.
• Educational & Laboratory Use: Supplied to academic and quality control laboratories for teaching and routine analysis of digitalis compounds.

Basic Information

Product Name	Digitoxin
CAS No.	71-63-6
Molecular Formula	C₄₁H₆₄O₁₃
Molecular Weight	764.94 g/mol
Synonyms	Digitoxin; Digitaline; Crystodigin; Cardigin; Carditoxin; Digitophyllin; Digisidin; DTX; (3β,5β)-3-[(O-2,6-Dideoxy-β-D-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-14-hydroxycard-20(22)-enolide
EINECS	200-758-5

Quality Control

Our Digitoxin is manufactured and tested under strict quality management systems. We offer grades suitable for use as a pharmaceutical reference standard, with specifications aligned with major pharmacopeias. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.