Description

2-(4-Boc-Piperazino-1-Yl)-5-Fluorobenzaldehyde is a high-purity, advanced pharmaceutical intermediate featuring a protected piperazine moiety and a reactive aldehyde group. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug discovery. It is primarily utilized by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of novel small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, especially kinase inhibitors and receptor antagonists.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a versatile linker component connecting E3 ligase ligands to target protein binders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize potency and pharmacokinetic properties of lead compounds.
• Custom Synthesis: Employed in the contract manufacturing of bespoke molecules for preclinical and clinical trial materials.
• Chemical Biology Probes: Facilitates the creation of labeled compounds for target identification and validation studies.

Basic Information

Product Name	2-(4-Boc-Piperazino-1-Yl)-5-Fluorobenzaldehyde
CAS No.	697305-53-6
Molecular Formula	C₁₆H₂₁FN₂O₃
Molecular Weight	308.35 g/mol
Synonyms	5-Fluoro-2-[4-[(1,1-dimethylethoxy)carbonyl]-1-piperazinyl]benzaldehyde; 2-(4-(tert-Butoxycarbonyl)piperazin-1-yl)-5-fluorobenzaldehyde; tert-Butyl 4-(2-formyl-4-fluorophenyl)piperazine-1-carboxylate; N-Boc-4-(5-fluoro-2-formylphenyl)piperazine; 697305-53-6; Boc-Pip-F-benzaldehyde
EINECS	Contact for details

Quality Control

Every batch of 2-(4-Boc-Piperazino-1-Yl)-5-Fluorobenzaldehyde is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation, meeting the exacting standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and full spectroscopic data is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation and degradation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.