Description

Benzeneacetaldehyde, α-Ethylidene-4-Fluoro-, (Alphae)- (9Ci) is a specialized fluorinated aromatic aldehyde building block with significant utility in advanced organic synthesis. This compound matters for its role as a key chiral intermediate in the development of active pharmaceutical ingredients (APIs) and complex agrochemicals, where the introduction of fluorine atoms is critical for modulating biological activity and metabolic stability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to incorporate a specific fluorinated phenylacetaldehyde moiety into their target molecules.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral precursor in the synthesis of novel fluorinated drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atom enhances lipophilicity and environmental stability.
• Ligand and Catalyst Development: Employed in the creation of specialized chiral ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Fine Chemical and Flavor/Fragrance Research: Acts as a building block for complex aromatic molecules in high-value chemical sectors.
• Material Science: Potential monomer or cross-linking agent in the development of specialty polymers with unique optical or electronic properties.
• Academic and Contract Research: A valuable reagent for methodological studies in organic chemistry, particularly in fluorination and asymmetric synthesis.

Basic Information

Product Name	Benzeneacetaldehyde, α-Ethylidene-4-Fluoro-, (Alphae)- (9Ci)
CAS No.	694513-38-7
Molecular Formula	C10H9FO
Molecular Weight	164.18 g/mol
Synonyms	4-Fluoro-α-ethylidenebenzenecetaldehyde; (αE)-α-Ethylidene-4-fluorobenzeneacetaldehyde; 2-(4-Fluorophenyl)-2-butenal; 4-Fluoro-α-ethylidenephenylacetaldehyde; (E)-2-(4-Fluorophenyl)but-2-enal; α-Ethylidene-4-fluorobenzeneacetaldehyde
EINECS	Contact for details

Quality Control

Our Benzeneacetaldehyde, α-Ethylidene-4-Fluoro-, (Alphae)- (9Ci) is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment, to ensure compliance with exacting R&D and process chemistry standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We support development from milligram to kilogram scale with consistent quality.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. This material is easily oxidized and light-sensitive; prolonged exposure to air or light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (E-isomer)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.