Description

4-(6-Amino-Pyrimidin-4-Yloxy)-Piperidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its piperidine and pyrimidine functional groups. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in kinase inhibitor research and development. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers requiring a reliable and consistent building block for complex organic synthesis.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of kinase inhibitors and other targeted therapeutic agents.
• Organic Synthesis: Used in medicinal chemistry for the construction of complex heterocyclic compounds and molecular scaffolds.
• Research & Development: Essential for academic and industrial research programs focused on drug discovery and process chemistry.
• Fine Chemical Production: Serves as a precursor in the multi-step synthesis of high-value specialty chemicals.
• Bioconjugation Chemistry: Potential use in the development of linker molecules for antibody-drug conjugates (ADCs) due to its reactive amine group.

Basic Information

Product Name	4-(6-Amino-Pyrimidin-4-Yloxy)-Piperidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	691400-74-5
Molecular Formula	C14H22N4O3
Molecular Weight	294.35 g/mol
Synonyms	tert-Butyl 4-[(6-aminopyrimidin-4-yl)oxy]piperidine-1-carboxylate; 1-Boc-4-[(6-aminopyrimidin-4-yl)oxy]piperidine; 4-(6-Amino-4-pyrimidinyloxy)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; 4-(6-Amino-pyrimidin-4-yloxy)-piperidine-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-4-[(6-aminopyrimidin-4-yl)oxy]piperidine; Boc-4-(6-aminopyrimidin-4-yloxy)piperidine; 691400-74-5
EINECS	Contact for details

Quality Control

Our 4-(6-Amino-Pyrimidin-4-Yloxy)-Piperidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) is provided with every shipment, detailing all specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.