Description

2',3'-o-Isopropylidene-4'-α-Azido-Uridine is a high-purity, protected nucleoside derivative, specifically designed for advanced synthetic chemistry applications. This compound serves as a critical building block in the synthesis of modified oligonucleotides and nucleoside analogs, enabling the development of novel therapeutics and research tools. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and academic research institutions focused on antiviral drug discovery, nucleic acid chemistry, and probe development.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel nucleoside-based antiviral and anticancer agents.
• Oligonucleotide Synthesis: Used as a modified monomer for introducing azido-functionalized nucleotides into DNA/RNA strands for click chemistry applications.
• Bioconjugation & Probe Development: The azido group enables efficient bioorthogonal "click" reactions (e.g., CuAAC, SPAAC) for labeling and conjugating biomolecules.
• Chemical Biology Research: Employed in studying nucleic acid structure, function, and metabolism through site-specific modification.
• Glycosylation Chemistry: Acts as a glycosyl donor or acceptor in the synthesis of complex nucleoside derivatives.
• Antiviral Drug Candidate Development: Investigated for its potential as a scaffold in the design of drugs targeting viral polymerases.

Basic Information

Product Name	2',3'-o-Isopropylidene-4'-α-Azido-Uridine
CAS No.	690271-27-3
Molecular Formula	C₁₂H₁₅N₅O₆
Molecular Weight	325.28 g/mol
Synonyms	4'-Azido-2',3'-O-isopropylideneuridine; 4'-Azido-2',3'-O-isopropylidene-uridine; 4'-Azido-2',3'-O-(1-methylethylidene)uridine; 4'-Azidouridine 2',3'-acetonide; 4'-α-Azido-2',3'-O-isopropylideneuridine; 2',3'-O-Isopropylidene-4'-azidouridine; 4'-Azido-2',3'-O-(1-methylethylidene)-β-D-ribofuranosyluracil
EINECS	Contact for details

Quality Control

Our 2',3'-o-Isopropylidene-4'-α-Azido-Uridine is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant quality guidelines to support its use in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.