Description

2-Phenyl-1-((Tetrahydrofuran-2-Yl)Methyl)-5,6,7,8-Tetrahydroquinazoline-4(1H)-Thione is a high-purity, advanced pharmaceutical intermediate with the CAS number 685551-25-1. This compound is a critical building block in modern medicinal chemistry, valued for its unique heterocyclic scaffold that serves as a core structure for developing novel therapeutic agents. It is primarily sought by research institutions and pharmaceutical manufacturers engaged in the synthesis of new chemical entities (NCEs) for drug discovery programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel small-molecule drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery.
• Chemical Biology Probes: Serves as a core structure for developing molecular probes to study biological processes and enzyme functions.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for client projects.
• Academic Research: Utilized in university and institutional labs for exploring new synthetic methodologies and heterocyclic chemistry.
• Library Synthesis: Employed in the generation of diverse compound libraries for high-throughput screening (HTS) campaigns.

Basic Information

Product Name	2-Phenyl-1-((Tetrahydrofuran-2-Yl)Methyl)-5,6,7,8-Tetrahydroquinazoline-4(1H)-Thione
CAS No.	685551-25-1
Molecular Formula	C20H22N2OS
Molecular Weight	338.47 g/mol
Synonyms	4(1H)-Thione, 2-Phenyl-1-[(tetrahydro-2-furanyl)methyl]-5,6,7,8-tetrahydroquinazoline; 1-[(Oxolan-2-yl)methyl]-2-phenyl-5,6,7,8-tetrahydroquinazoline-4-thione; 2-Phenyl-1-(tetrahydrofuran-2-ylmethyl)-5,6,7,8-tetrahydro-4H-quinazoline-4-thione; 4-Thioxo-2-phenyl-1-(tetrahydrofuran-2-ylmethyl)-1,4,5,6,7,8-hexahydroquinazoline; THF-Methyl-Tetrahydroquinazolinethione Derivative
EINECS	Contact for details

Quality Control

Our 2-Phenyl-1-((Tetrahydrofuran-2-Yl)Methyl)-5,6,7,8-Tetrahydroquinazoline-4(1H)-Thione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR, MS), to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This material is light-sensitive (store away from light) and hygroscopic (moisture-sensitive). Keep the container tightly sealed under an inert atmosphere to prevent oxidation and moisture absorption.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.