Description

2-Pyrrolidin-1-Yl-6-Trifluoromethyl-Pyrimidin-4-Ol is a high-purity, advanced pharmaceutical intermediate characterized by its unique pyrimidine core functionalized with pyrrolidine and trifluoromethyl groups. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular scaffolds. It is essential for R&D and production teams in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop new compounds with enhanced biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, especially for kinase inhibitors and other small molecule therapeutics.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and pesticides, leveraging the biological activity of the pyrimidine structure.
• Chemical Biology & Proteomics: Serves as a versatile scaffold for designing chemical probes and tool compounds to study biological pathways and protein function.
• Material Science Precursor: Potential use in the development of advanced organic materials, such as ligands for catalysis or components in organic electronics.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for client projects.

Basic Information

Product Name	2-Pyrrolidin-1-Yl-6-Trifluoromethyl-Pyrimidin-4-Ol
CAS No.	685113-04-6
Molecular Formula	C9H10F3N3O
Molecular Weight	233.19 g/mol
Synonyms	4-Hydroxy-2-(1-pyrrolidinyl)-6-(trifluoromethyl)pyrimidine; 6-(Trifluoromethyl)-2-(pyrrolidin-1-yl)pyrimidin-4-ol; 2-(Pyrrolidin-1-yl)-6-(trifluoromethyl)pyrimidin-4-ol; 685113-04-6; 2-Pyrrolidino-6-trifluoromethyl-4-pyrimidinol; 4-Pyrimidinol, 2-(1-pyrrolidinyl)-6-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 2-Pyrrolidin-1-Yl-6-Trifluoromethyl-Pyrimidin-4-Ol is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is sensitive to light (store away from light) and may be incompatible with strong bases and fluorides. Keep away from heat and ignition sources. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.