Description

2,4-Difluoro-6-((Trimethylsilyl)Ethynyl)Aniline is a specialized aniline derivative featuring both fluorine substituents and a protected ethynyl group. This compound is a high-value intermediate prized for its role in constructing complex molecular architectures, particularly in advanced materials and pharmaceuticals. It is essential for researchers and process chemists in the fields of organic synthesis, medicinal chemistry, and materials science who require a reliable source of this building block for developing new active compounds and functional polymers.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides and fungicides, leveraging the fluorine atoms for enhanced biological activity and environmental stability.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the production of specialty polymers, liquid crystals, and organic electronic materials.
• Organic Synthesis Reagent: Employed in Sonogashira and other cross-coupling reactions to introduce an ethynyl moiety into complex molecules, facilitated by the trimethylsilyl protecting group.
• Fluorescent Dye & Sensor Development: Acts as a core structure for creating advanced fluorophores and molecular sensors due to the tunable electronic properties of the aniline and acetylene groups.

Basic Information

Product Name	2,4-Difluoro-6-((Trimethylsilyl)Ethynyl)Aniline
CAS No.	684250-21-3
Molecular Formula	C11H13F2NSi
Molecular Weight	225.31 g/mol
Synonyms	6-Ethynyl-2,4-difluoroaniline, trimethylsilyl derivative; 2,4-Difluoro-6-(2-trimethylsilylethynyl)aniline; 2,4-Difluoro-6-[(trimethylsilyl)ethynyl]benzenamine; 6-((Trimethylsilyl)ethynyl)-2,4-difluoroaniline; Benzenamine, 2,4-difluoro-6-[(trimethylsilyl)ethynyl]-; TMS-Protected 2,4-Difluoro-6-ethynylaniline
EINECS	Contact for details

Quality Control

Every batch of 2,4-Difluoro-6-((Trimethylsilyl)Ethynyl)Aniline is manufactured and tested under strict quality management systems. We ensure the product meets high-purity standards suitable for research and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles via HPLC, GC, and NMR is provided with each shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool (15-25°C), dry place. Due to its hygroscopic and easily oxidized nature, the container should be opened minimally and handled in a moisture-controlled environment.

Specification

Item	Specification
Appearance	Light yellow to brown crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.