Description

2-(4-[4-(Trifluoromethyl)Pyrimidin-2-Yl]Piperazin-1-Yl)Ethylamine is a high-value, multi-functional chemical building block featuring a piperazine core linked to a trifluoromethylpyrimidine moiety. This compound is critical for research and development in advanced pharmaceutical chemistry, where its unique structure enables the creation of novel bioactive molecules. It is primarily sought after by medicinal chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of targeted therapeutics and crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other targeted therapies.
• Medicinal Chemistry Research: Used extensively in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR).
• Agrochemical Development: Serves as a building block for novel herbicides, fungicides, and insecticides, leveraging the biological activity of the pyrimidine ring.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying enzyme function and cellular pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds for client projects.

Basic Information

Product Name	2-(4-[4-(Trifluoromethyl)Pyrimidin-2-Yl]Piperazin-1-Yl)Ethylamine
CAS No.	683274-53-5
Molecular Formula	C11H15F3N5
Molecular Weight	274.27 g/mol
Synonyms	2-[4-[4-(Trifluoromethyl)pyrimidin-2-yl]piperazin-1-yl]ethanamine; 1-[2-Aminoethyl]-4-[4-(trifluoromethyl)-2-pyrimidinyl]piperazine; 2-(4-(4-(Trifluoromethyl)pyrimidin-2-yl)piperazin-1-yl)ethan-1-amine; N-(2-Aminoethyl)-4-(4-trifluoromethyl-2-pyrimidinyl)piperazine; 683274-53-5; 2-Piperazin-1-ylethylamine, 4-(4-trifluoromethylpyrimidin-2-yl) derivative
EINECS	Contact for details

Quality Control

Our 2-(4-[4-(Trifluoromethyl)Pyrimidin-2-Yl]Piperazin-1-Yl)Ethylamine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.