Description

3-Amino-3-(3-Trifluoromethyl-Phenyl)-Propan-1-Ol is a high-value trifluoromethylated amino alcohol building block, essential for the synthesis of advanced pharmaceutical intermediates and fine chemicals. Its unique structure, featuring both an amino and a hydroxyl group on a propanol backbone adjacent to a trifluoromethylphenyl ring, makes it a versatile chiral synthon for medicinal chemistry. This compound is primarily sought after by R&D and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of potential drug candidates, particularly in central nervous system (CNS) and oncology research.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group imparts desirable properties.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, including dyes, pigments, and advanced polymers.
• Academic & Industrial Research: A valuable compound for methodological development in organic synthesis and fluorine chemistry studies.

Basic Information

Product Name	3-Amino-3-(3-Trifluoromethyl-Phenyl)-Propan-1-Ol
CAS No.	683221-00-3
Molecular Formula	C10H12F3NO
Molecular Weight	219.20 g/mol
Synonyms	3-Amino-3-(3-(trifluoromethyl)phenyl)propan-1-ol; 3-Amino-1-(3-trifluoromethylphenyl)-1-propanol; 1-Propanol, 3-amino-3-[3-(trifluoromethyl)phenyl]-; 3-(3-Aminopropyl)-α,α,α-trifluorotoluene; β-Amino-3'-(trifluoromethyl)benzenepropanol; γ-Amino-β-(3-trifluoromethylphenyl)propanol; (RS)-3-Amino-3-(3-trifluoromethylphenyl)propan-1-ol
EINECS	Contact for details

Quality Control

Our 3-Amino-3-(3-Trifluoromethyl-Phenyl)-Propan-1-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and chiral purity analysis, to ensure it meets the high standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We support cGMP and ISO 9001 compliant production for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (or as specified)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.