Description

n-Fmoc-2-Piperidineacetic Acid is a high-purity, protected amino acid derivative essential for advanced organic synthesis. This compound serves as a critical building block in the construction of complex peptides and peptidomimetics, offering precise control over molecular architecture. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical industries for drug discovery and development projects.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected intermediate for the controlled assembly of peptide chains.
• Peptidomimetic Drug Development: Used to incorporate constrained piperidine scaffolds into novel therapeutic candidates targeting GPCRs and enzymes.
• Combinatorial Chemistry Libraries: Serves as a versatile scaffold for generating diverse compound libraries for high-throughput screening.
• Linker and Conjugate Synthesis: Employed in the synthesis of drug-linker systems for antibody-drug conjugates (ADCs) and other bioconjugates.
• Medicinal Chemistry Research: Facilitates structure-activity relationship (SAR) studies by introducing specific conformational constraints.
• Custom Peptide Service Providers: A fundamental reagent for CROs and CDMOs offering bespoke peptide manufacturing.

Basic Information

Product Name	n-Fmoc-2-Piperidineacetic Acid
CAS No.	683220-37-3
Molecular Formula	C₂₂H₂₃NO₄
Molecular Weight	365.42 g/mol
Synonyms	2-[(9H-Fluoren-9-ylmethoxy)carbonyl]-1,2,3,4,5,6-hexahydro-2-pyridineacetic Acid; Fmoc-2-Piperidineacetic Acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]piperidine-2-acetic Acid; 1-Fmoc-piperidine-2-acetic Acid; (2-Piperidyl)acetic Acid N-Fmoc Derivative; Fmoc-Pip(2)-OH; N-α-Fmoc-2-piperidineacetic Acid
EINECS	Contact for details

Quality Control

Our n-Fmoc-2-Piperidineacetic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the exacting standards required for pharmaceutical research and development. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach ambient temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.