Description

Fmoc-D-Thr(Trt)-Oh is a high-purity, protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound is critical for researchers and manufacturers requiring precise stereochemical control and high coupling efficiency in the synthesis of complex peptides and peptidomimetics. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and CROs/CMOs developing therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key building block for the controlled, sequential assembly of peptide chains using Fmoc-chemistry protocols.
• Therapeutic Peptide Development: For the research and production of peptide-based drugs targeting metabolic disorders, oncology, and infectious diseases.
• Peptidomimetic & Protein Engineering: Enables the incorporation of non-natural or modified threonine residues to enhance stability, activity, or bioavailability of engineered biomolecules.
• Combinatorial Chemistry Libraries: Serves as a valuable reagent for generating diverse peptide libraries used in high-throughput screening for drug discovery.
• Bioconjugation & Labeling: Used in the preparation of peptide conjugates for diagnostic imaging, targeted drug delivery, and affinity chromatography.
• Academic & Industrial Research: A fundamental reagent for biochemical studies investigating protein structure-function relationships and signal transduction pathways.

Basic Information

Product Name	Fmoc-D-Thr(Trt)-Oh
CAS No.	682800-84-6
Molecular Formula	C39H35NO5
Molecular Weight	597.70 g/mol
Synonyms	Fmoc-D-threonine(trityl)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-(triphenylmethyl)-D-threonine; Fmoc-D-Thr(Trityl)-OH; Fmoc-D-Thr(Trt)-OH; N-α-Fmoc-O-trityl-D-threonine; (2R,3R)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-((trityl)oxy)butanoic acid; D-Threonine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, 3-(triphenylmethyl) ether
EINECS	Contact for details

Quality Control

Our Fmoc-D-Thr(Trt)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive applications like peptide synthesis. Each lot undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. This material is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to prevent degradation. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.