Description

Astressin2B Trifluoroacetate Salt is a potent and selective corticotropin-releasing factor receptor 2 (CRF2) antagonist, widely used in advanced neuroendocrine and stress-related research. This high-purity compound is critical for investigating the physiological and behavioral pathways associated with stress, anxiety, and related disorders. It is an essential research-grade biochemical for pharmaceutical R&D, academic institutions, and contract research organizations (CROs) focused on neuroscience and drug discovery.

Application

• Neuroscience Research: A key tool for studying the role of CRF2 receptors in stress response, anxiety, depression, and addiction models.
• Pharmacological Studies: Used in in vitro and in vivo assays to characterize receptor binding, antagonism, and signal transduction pathways.
• Drug Discovery & Development: Serves as a reference standard and lead compound in the development of novel therapeutics targeting stress-related disorders.
• Endocrine Research: Investigates the modulation of the hypothalamic-pituitary-adrenal (HPA) axis and related neuroendocrine functions.
• Behavioral Pharmacology: Applied in animal models to elucidate the behavioral effects of CRF system modulation.
• Biochemical Assay Development: Used as a critical reagent in high-throughput screening (HTS) and functional assay development.

Basic Information

Product Name	Astressin2B Trifluoroacetate Salt
CAS No.	681260-70-8
Molecular Formula	C152H246N50O39 • xC2HF3O2
Molecular Weight	~3380.9 g/mol (free base)
Synonyms	Astressin 2B TFA Salt; Cyclo(31-34)[DPhe12,Nle21,38,Glu30,Lys33]Ac-hCRF-(12-41); hCRF-(12-41), Cyclo(31-34)[DPhe12,Nle21,38,Glu30,Lys33]Ac-; CRF2 Receptor Antagonist; Astressin-2B; Ac-[DPhe12,Nle21,38, Glu30, Lys33]hCRF-(12-41)
EINECS	Contact for details

Quality Control

Our Astressin2B Trifluoroacetate Salt is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high biological activity. Each lot is characterized using advanced analytical techniques, including HPLC and mass spectrometry, to confirm identity, purity, and peptide content. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and related substances is provided with every shipment to support your research compliance and documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to theoretical mass
Purity (HPLC)	≥95%
Peptide Content	≥70%
Water Content (KF)	≤8.0%
Trifluoroacetate Content (HPLC/NMR)	≤15%
Solubility	Soluble in water, DMSO, acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.