Description

3,3-Difluorocyclobutylmethyl Tosylate is a high-value fluorinated building block and pharmaceutical intermediate. This compound is crucial for introducing the rigid, lipophilic 3,3-difluorocyclobutyl moiety into target molecules, a key strategy in modern drug design for modulating potency, metabolic stability, and physicochemical properties. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of small molecule drugs targeting kinases, GPCRs, and other biological targets.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization to improve drug-like properties.
• Agrochemical Research: Intermediate in the development of new herbicides, fungicides, and insecticides with enhanced efficacy.
• Fluorine Chemistry: Serves as a versatile reagent for introducing fluorinated cyclobutyl groups in organic synthesis.
• Material Science: Potential precursor for specialty polymers and advanced materials requiring specific fluorinated segments.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations engaged in custom synthesis and development services.

Basic Information

Product Name	3,3-Difluorocyclobutylmethyl Tosylate
CAS No.	681128-40-5
Molecular Formula	C13H16F2O3S
Molecular Weight	290.33 g/mol
Synonyms	3,3-Difluorocyclobutylmethyl 4-methylbenzenesulfonate; (3,3-Difluorocyclobutyl)methyl p-toluenesulfonate; p-Toluenesulfonic acid 3,3-difluorocyclobutylmethyl ester; 3,3-Difluorocyclobutylmethyl Tosylate; (3,3-Difluorocyclobutyl)methyl Tosylate; Tosic acid 3,3-difluorocyclobutylmethyl ester; DFCMT
EINECS	Contact for details

Quality Control

Our 3,3-Difluorocyclobutylmethyl Tosylate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. We provide comprehensive analytical data, including HPLC purity, NMR, and MS characterization. Certificates of Analysis (COA) detailing all specifications are available upon request to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.