Description

Cyclobutanecarboxylic Acid, 3,3-Difluoro-, Ethyl Ester (9Ci) is a high-purity fluorinated building block essential for advanced organic synthesis. This compound matters for its unique structural motif, combining the constrained geometry of a cyclobutane ring with the electronic influence of fluorine atoms, making it a valuable intermediate in medicinal chemistry and materials science. It is primarily needed by research and development chemists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for introducing the difluorocyclobutyl moiety to modulate pharmacokinetic properties.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides where the fluorinated cyclobutane structure can enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for designing novel chiral ligands and organocatalysts in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of fluorinated polymers and advanced organic materials with specific electronic or surface properties.
• Chemical Biology Probes: Useful for synthesizing labeled compounds and molecular probes for studying biological mechanisms and target engagement.

Basic Information

Product Name	Cyclobutanecarboxylic Acid, 3,3-Difluoro-, Ethyl Ester (9Ci)
CAS No.	681128-38-1
Molecular Formula	C7H10F2O2
Molecular Weight	164.15 g/mol
Synonyms	Ethyl 3,3-Difluorocyclobutanecarboxylate; 3,3-Difluorocyclobutanecarboxylic Acid Ethyl Ester; 681128-38-1; Ethyl 3,3-Difluorocyclobutanecarboxylate (9CI); 3,3-Difluorocyclobutanecarboxylic Acid Ethyl Ester (9CI); Cyclobutanecarboxylic acid, 3,3-difluoro-, ethyl ester; Ethyl 3,3-difluorocyclobutane-1-carboxylate
EINECS	Contact for details

Quality Control

Our Cyclobutanecarboxylic Acid, 3,3-Difluoro-, Ethyl Ester (9Ci) is produced under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) documenting full specifications are provided and available upon request, supporting your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids, strong bases, and oxidizing agents. Recommended storage temperature is between 2°C and 8°C for long-term stability, although the product is typically stable at controlled room temperature for shorter periods. Keep container tightly sealed when not in use to prevent moisture absorption or contamination.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC)	≥ 97.0%
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.