Description

4(1H)-Pyrimidinone, 6-Hydrazino-2,3-Dihydro-2-Thioxo- (9Ci) CAS NO 678974-38-4 is a specialized heterocyclic building block featuring a reactive hydrazino group adjacent to a thioxo-pyrimidinone core. This compound matters for its role as a versatile intermediate in the synthesis of complex pharmacologically active molecules, particularly in medicinal chemistry research. It is primarily needed by pharmaceutical R&D laboratories and fine chemical manufacturers developing novel drug candidates, especially in areas like kinase inhibitors and antiviral agents.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel small-molecule therapeutics, particularly kinase inhibitors and antiviral compounds.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes due to its reactive hydrazine moiety.
• Heterocyclic Compound Synthesis: Serves as a foundational building block for constructing more complex fused or substituted pyrimidine derivatives.
• Agrochemical Development: Potential intermediate in the research and synthesis of new active ingredients for crop protection products.
• Chemical Biology Probes: Can be utilized to create molecular probes for studying enzyme function and biological pathways.

Basic Information

Product Name	4(1H)-Pyrimidinone, 6-Hydrazino-2,3-Dihydro-2-Thioxo- (9Ci)
CAS No.	678974-38-4
Molecular Formula	C4H6N4OS
Molecular Weight	158.18 g/mol
Synonyms	6-Hydrazino-2-thioxo-2,3-dihydro-4(1H)-pyrimidinone; 6-Hydrazinyl-2-sulfanylidene-1,2-dihydropyrimidin-4-one; 2,3-Dihydro-6-hydrazino-2-thioxo-4(1H)-pyrimidinone; 6-Hydrazino-2-mercapto-4-pyrimidinol; 4-Pyrimidinol, 6-hydrazino-2,3-dihydro-2-thioxo-; CAS 678974-38-4
EINECS	Contact for details

Quality Control

Our 4(1H)-Pyrimidinone, 6-Hydrazino-2,3-Dihydro-2-Thioxo- (9Ci) is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR), to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at 2-8°C to minimize oxidation and degradation. This material is easily oxidized and should be handled with care to avoid prolonged exposure to air. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.