Description

2,3-Difluoro-4-Hydroxybenzaldehyde is a versatile fluorinated aromatic aldehyde building block of significant interest in advanced organic synthesis. Its molecular structure, featuring both aldehyde and phenolic hydroxyl groups on a difluorinated benzene ring, makes it a critical precursor for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, where the introduction of fluorine atoms can dramatically alter biological activity, metabolic stability, and lipophilicity.

Application

• Pharmaceutical Intermediate: A key starting material for synthesizing fluorinated drug candidates, particularly in therapeutic areas like oncology, central nervous system (CNS) disorders, and anti-infectives.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where fluorination enhances efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated mesogens and electron-transport materials, improving the performance and stability of display and lighting technologies.
• Polymer Modification: Incorporated as a monomer or cross-linking agent to create specialty polymers with enhanced chemical resistance, thermal stability, or specific surface properties.
• Complex Ligand & Catalyst Development: Utilized in organometallic chemistry to create sophisticated ligands for catalysis, enabling more efficient and selective chemical transformations.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological studies and the exploration of new fluorination chemistry and reaction pathways.

Basic Information

Product Name	2,3-Difluoro-4-Hydroxybenzaldehyde
CAS No.	676500-39-3
Molecular Formula	C7H4F2O2
Molecular Weight	158.10 g/mol
Synonyms	4-Hydroxy-2,3-difluorobenzaldehyde; 2,3-Difluoro-4-hydroxybenzaldehyde; 2,3-Difluoro-4-formylphenol; Benzaldehyde, 2,3-difluoro-4-hydroxy-; 4-Formyl-2,3-difluorophenol
EINECS	Contact for details

Quality Control

Every batch of 2,3-Difluoro-4-Hydroxybenzaldehyde is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements for advanced synthetic applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as purity (by HPLC), identity confirmation (by FT-IR and NMR), and levels of specific impurities. Our quality commitment supports compliance with relevant guidelines for use in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents, strong bases, and reducing agents. Due to its light-sensitive nature, prolonged exposure to light should be avoided to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.