Description

3-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)Bicyclo[1.1.1]Pentane-1-Carboxylicacid is a specialized, high-value building block designed for advanced pharmaceutical and bioconjugation research. This compound is critical for the synthesis of novel drug candidates, particularly in the development of peptide-based therapeutics and PROTACs (Proteolysis Targeting Chimeras). It is primarily utilized by research scientists and process chemists in pharmaceutical R&D, biotechnology, and fine chemical synthesis for introducing the rigid, three-dimensional bicyclo[1.1.1]pentane (BCP) scaffold, which is a valuable isostere for tert-butyl or aromatic rings to improve metabolic stability and physicochemical properties.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel Active Pharmaceutical Ingredients (APIs) targeting various disease pathways.
• Peptide Synthesis: Used in Solid-Phase Peptide Synthesis (SPPS) as an Fmoc-protected amino acid derivative to incorporate the BCP motif into peptide chains.
• PROTAC & Molecular Glue Development: Serves as a linker or component in the design of bifunctional degraders for targeted protein degradation.
• Bioconjugation: Facilitates the site-specific labeling and modification of proteins, antibodies, and other biomolecules.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to explore novel chemical space and optimize drug-like properties.
• Chemical Biology Probes: Integral for creating tool compounds and probes to study biological processes and target engagement.

Basic Information

Product Name	3-((((9H-Fluoren-9-Yl)Methoxy)Carbonyl)Amino)Bicyclo[1.1.1]Pentane-1-Carboxylicacid
CAS No.	676371-66-7
Molecular Formula	C21H19NO4
Molecular Weight	349.38 g/mol
Synonyms	Fmoc-BCP-OH; Fmoc-3-Aminobicyclo[1.1.1]pentane-1-carboxylic acid; 1-[(9H-Fluoren-9-ylmethoxy)carbonylamino]bicyclo[1.1.1]pentane-3-carboxylic acid; Fmoc-3-Amino-BCP-acid; 3-(Fmoc-amino)bicyclo[1.1.1]pentane-1-carboxylic acid; BCP-Fmoc; Fmoc-NH-BCP-COOH; (1r,3s)-3-(((9H-Fluoren-9-yl)methoxy)carbonylamino)bicyclo[1.1.1]pentane-1-carboxylic acid
EINECS	Contact for details

Quality Control

Our production of this advanced pharmaceutical intermediate adheres to stringent quality protocols. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and Mass Spectrometry. We provide detailed Certificates of Analysis (COA) with each shipment, ensuring traceability and compliance with customer-specific requirements and cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.