Description

Pyrimidine, 4,6-Difluoro-2-(1-Piperazinyl)- (9Ci) is a high-value, fluorinated heterocyclic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular modification. Pharmaceutical R&D teams and fine chemical manufacturers need this specialized chemical to create next-generation drug candidates with enhanced biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel kinase inhibitors and other targeted small-molecule therapeutics.
• Agrochemical Research: Used in the development of new fungicides and herbicides, leveraging the biological activity of the difluoropyrimidine core.
• Chemical Biology Probe Development: Employed as a scaffold for creating molecular probes to study enzyme function and cellular signaling pathways.
• Material Science Research: Investigated as a building block for advanced organic electronic materials and liquid crystals due to its aromatic and heterocyclic structure.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects.

Basic Information

Product Name	Pyrimidine, 4,6-Difluoro-2-(1-Piperazinyl)- (9Ci)
CAS No.	675588-43-9
Molecular Formula	C8H10F2N4
Molecular Weight	200.19 g/mol
Synonyms	4,6-Difluoro-2-(piperazin-1-yl)pyrimidine; 2-(1-Piperazinyl)-4,6-difluoropyrimidine; 1-(4,6-Difluoropyrimidin-2-yl)piperazine; 4,6-Difluoro-2-piperazin-1-ylpyrimidine; 675588-43-9; 4,6-Difluoro-2-(piperazin-1-yl)pyrimidine; Difluoropyrimidine-piperazine derivative
EINECS	Contact for details

Quality Control

Our Pyrimidine, 4,6-Difluoro-2-(1-Piperazinyl)- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong acids and strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.