Description

Methyl 4-{[2-(5-Chloro-2-Fluorophenyl)-5-Methoxypyrimidin-4-Yl]Amino}Nicotinate is a high-purity, advanced pharmaceutical intermediate with the CAS number 674793-50-1. This compound is critical for the research and development of novel therapeutic agents, particularly in oncology and targeted drug discovery. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in synthesizing complex bioactive molecules.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of investigational new drugs (INDs) and active pharmaceutical ingredients (APIs).
• Kinase Inhibitor Research: Core scaffold for the development of small-molecule kinase inhibitors targeting specific cancer pathways.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization processes.
• Preclinical Development: Serves as a critical material for producing batches required for pharmacological and toxicological studies.
• Custom Synthesis: Starting point for contract manufacturing organizations (CMOs) producing bespoke compounds for client pipelines.
• Academic Research: Employed in university and institutional labs for biochemical and pharmacological research projects.

Basic Information

Product Name	Methyl 4-{[2-(5-Chloro-2-Fluorophenyl)-5-Methoxypyrimidin-4-Yl]Amino}Nicotinate
CAS No.	674793-50-1
Molecular Formula	C18H14ClFN4O3
Molecular Weight	388.78 g/mol
Synonyms	4-[[2-(5-Chloro-2-fluorophenyl)-5-methoxy-4-pyrimidinyl]amino]-3-pyridinecarboxylic acid methyl ester; Methyl 4-((2-(5-chloro-2-fluorophenyl)-5-methoxypyrimidin-4-yl)amino)nicotinate; 674793-50-1; UNII-9B9V6S3A4T; 9B9V6S3A4T; Nicotinic acid, 4-[[2-(5-chloro-2-fluorophenyl)-5-methoxy-4-pyrimidinyl]amino]-, methyl ester; BDBM50389339; AKOS025310065
EINECS	Contact for details

Quality Control

Our Methyl 4-{[2-(5-Chloro-2-Fluorophenyl)-5-Methoxypyrimidin-4-Yl]Amino}Nicotinate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive (store away from light). Keep the container tightly sealed in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.