Description

A-Conotoxin Pia is a highly specific and potent peptide neurotoxin derived from the venom of cone snails, with the CAS registry number 669050-68-4. This compound is a critical research tool for selectively targeting and modulating specific subtypes of nicotinic acetylcholine receptors (nAChRs) in neurological studies. It is essential for researchers and pharmaceutical developers in neuroscience, pharmacology, and drug discovery who require precise ligands for receptor characterization and the development of novel therapeutic agents for pain and neurological disorders.

Application

• Neuroscience Research: A key pharmacological probe for studying the function and distribution of specific nAChR subtypes in the central and peripheral nervous systems.
• Drug Discovery & Development: Used in high-throughput screening and validation assays to identify and optimize new lead compounds targeting nAChRs for conditions like neuropathic pain.
• Pharmacological Characterization: Essential for in vitro and ex vivo studies to determine receptor binding affinity, selectivity, and mechanism of action.
• Academic & Institutional Research: Supports fundamental research in universities and institutes focused on synaptic transmission, signal transduction, and neuronal circuitry.
• Biochemical Assay Development: Serves as a standard or reference compound in developing and calibrating sensitive biochemical and electrophysiological assays.
• Toxicology Studies: Used to investigate the physiological effects of targeted ion channel blockade and to understand the action of conotoxin venoms.

Basic Information

Product Name	A-Conotoxin Pia
CAS No.	669050-68-4
Molecular Formula	C84H130N28O26S6
Molecular Weight	2045.4 g/mol
Synonyms	α-Conotoxin PIA; α-Conotoxin Pia; Conotoxin PIA; PIA Conotoxin; α-PIA; α-PIA; α-CTx PIA; A-Conotoxin PIA; α-Conotoxin Pia; PIA
EINECS	Contact for details

Quality Control

Every batch of A-Conotoxin Pia is produced and analyzed under stringent quality protocols to ensure the highest standards of purity and biological activity for research applications. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure identity, purity, and potency. Certificates of Analysis (COA) with detailed specifications for HPLC purity, peptide content, mass spectrometry confirmation, and biological activity are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture absorption. Aliquot reconstituted solutions to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (Mass Spec)	Conforms
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Biological Activity	Confirmed by assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.