Description

Fmoc-Gly(Nhboc)-Oh is a high-purity, orthogonally protected glycine derivative essential for modern solid-phase peptide synthesis (SPPS). This compound matters because it provides critical control over the sequential assembly of peptides, enabling the precise construction of complex biomolecules for research and therapeutic development. It is primarily needed by pharmaceutical R&D teams, biotechnology companies, and academic research laboratories focused on peptide-based drug discovery, proteomics, and biochemical studies.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a key building block for the controlled, sequential addition of glycine residues using Fmoc-chemistry protocols.
• Peptide Drug Intermediate: Used in the research and development of therapeutic peptides, including hormone analogs and enzyme inhibitors.
• Bioconjugation and Labeling: Facilitates the site-specific introduction of glycine linkers for attaching labels, tags, or other functional groups to biomolecules.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for high-throughput screening against biological targets.
• Academic & Biochemical Research: A fundamental reagent for studying protein structure-function relationships, enzyme kinetics, and molecular recognition processes.
• Custom Oligopeptide Production: Used by CROs and CDMOs for the contract synthesis of specific peptide sequences for clients.

Basic Information

Product Name	Fmoc-Gly(Nhboc)-Oh
CAS No.	668492-50-0
Molecular Formula	C₂₂H₂₄N₂O₆
Molecular Weight	412.44 g/mol
Synonyms	Fmoc-Gly(N-Boc)-OH; N-α-Fmoc-N-ε-Boc-glycine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-[(tert-butoxy)carbonyl]glycine; (2-(((9H-Fluoren-9-yl)methoxy)carbonyl)((tert-butoxy)carbonyl)amino)acetic acid; Fmoc-Gly(Boc)-OH; Boc-Gly(Fmoc)-OH; Glycine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-[(1,1-dimethylethoxy)carbonyl]-
EINECS	Contact for details

Quality Control

Our Fmoc-Gly(Nhboc)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive synthetic applications. Each lot undergoes rigorous analytical testing, including HPLC for purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.