Description

5-(4-Methoxy-Phenyl)-7-Trifluoromethyl-4,5,6,7-Tetrahydro-Pyrazolo[1,5-A]Pyrimidine-3-Carboxylic Acid Ethyl Ester is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular scaffolds. It is primarily sought by research institutions and manufacturers in the pharmaceutical and agrochemical industries for drug discovery and development programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, inflammatory diseases, and oncology.
• Agrochemical Research: Serves as a structural motif in the development of new pesticides and herbicides, leveraging the biological activity of the pyrazolopyrimidine core.
• Chemical Biology Probe: Used in academic and industrial research to study enzyme inhibition and protein-ligand interactions due to its privileged scaffold.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization studies for the commercial production of complex molecules.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific target molecules.

Basic Information

Item	Details
Product Name	5-(4-Methoxy-Phenyl)-7-Trifluoromethyl-4,5,6,7-Tetrahydro-Pyrazolo[1,5-A]Pyrimidine-3-Carboxylic Acid Ethyl Ester
CAS No.	667920-67-4
Molecular Formula	C17H16F3N3O3
Molecular Weight	367.33 g/mol
Synonyms	Ethyl 5-(4-methoxyphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxylate; 5-(4-Methoxyphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester; 667920-67-4; Pyrazolo[1,5-a]pyrimidine-3-carboxylic acid, 4,5,6,7-tetrahydro-5-(4-methoxyphenyl)-7-(trifluoromethyl)-, ethyl ester
EINECS	Contact for details

Quality Control

Our production of 5-(4-Methoxy-Phenyl)-7-Trifluoromethyl-4,5,6,7-Tetrahydro-Pyrazolo[1,5-A]Pyrimidine-3-Carboxylic Acid Ethyl Ester adheres to stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed immediately after use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.