Description

5-(Pentafluorosulfanyl)-1H-Indole is a high-value, fluorinated indole derivative characterized by the unique pentafluorosulfanyl (SF5) functional group. This compound matters as a sophisticated building block in advanced organic synthesis, offering exceptional metabolic stability, lipophilicity, and electronic properties sought after in modern material and life sciences. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty materials industries for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in central nervous system (CNS) and oncology research, where the SF5 group can enhance bioavailability and binding affinity.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, leveraging the group's stability and hydrophobic character to improve environmental persistence and efficacy.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis for asymmetric synthesis.
• Material Science Precursor: Employed in the synthesis of organic semiconductors, liquid crystals, and polymers where the SF5 moiety can tune electronic properties and thermal stability.
• Fluorine Chemistry & SAR Studies: An essential tool for structure-activity relationship (SAR) studies, allowing medicinal chemists to explore the "fluorine effect" with a bulkier, highly electronegative substituent.

Basic Information

Product Name	5-(Pentafluorosulfanyl)-1H-Indole
CAS No.	666841-01-6
Molecular Formula	C8H4F5NS
Molecular Weight	241.19 g/mol
Synonyms	5-(SF5)-1H-Indole; 5-(Pentafluorosulfanyl)indole; 1H-Indole, 5-(pentafluorosulfanyl)-; 5-(Pentafluorosulfuranyl)indole; 5-(SF5)Indole; 5-Pentafluorosulfanylindole; Indole, 5-(pentafluorosulfanyl)-
EINECS	Contact for details

Quality Control

Our 5-(Pentafluorosulfanyl)-1H-Indole is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your R&D and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.