Description

7-(Difluoromethyl)-5-Methyl-4,5,6,7-Tetrahydro[1,2,4]Triazolo[1,5-A]Pyrimidine-2-Carboxylic Acid (Saltdata: Free) is a high-purity, advanced pharmaceutical intermediate characterized by its fused triazolopyrimidine heterocyclic structure. This compound is of significant commercial interest for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular scaffolds. It is primarily sought by research institutions, agrochemical developers, and pharmaceutical companies engaged in medicinal chemistry and process development for new drug candidates.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of potential drug candidates, especially those targeting central nervous system (CNS) disorders or infectious diseases.
• Agrochemical Research: Serves as a core structure for developing new generation fungicides or herbicides, leveraging the biological activity of the triazolopyrimidine moiety.
• Medicinal Chemistry & SAR Studies: Used extensively in structure-activity relationship (SAR) studies to optimize potency, selectivity, and pharmacokinetic properties of lead compounds.
• Process Chemistry & Scale-Up: Employed in route scouting, optimization, and pilot-scale production for clinical trial material (CTM) manufacturing.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke molecules for client projects.
• Academic & Industrial R&D: A valuable reagent for exploratory research in heterocyclic chemistry and the development of new synthetic methodologies.

Basic Information

Product Name	7-(Difluoromethyl)-5-Methyl-4,5,6,7-Tetrahydro[1,2,4]Triazolo[1,5-A]Pyrimidine-2-Carboxylic Acid (Saltdata: Free)
CAS No.	664992-04-5
Molecular Formula	C9H10F2N4O2
Molecular Weight	244.20 g/mol
Synonyms	7-(Difluoromethyl)-5-methyl-4,5,6,7-tetrahydro[1,2,4]triazolo[1,5-a]pyrimidine-2-carboxylic acid; 7-(Difluoromethyl)-5-methyl-4,5,6,7-tetrahydro-1,2,4-triazolo[1,5-a]pyrimidine-2-carboxylic acid; 664992-04-5; 7-(Difluoromethyl)-5-methyl-4,5,6,7-tetrahydro[1,2,4]triazolo[1,5-a]pyrimidine-2-carboxylic acid; Triazolopyrimidine-2-carboxylic acid derivative; DFM-THP-TPCA.
EINECS	Contact for details

Quality Control

Our production of 7-(Difluoromethyl)-5-Methyl-4,5,6,7-Tetrahydro[1,2,4]Triazolo[1,5-A]Pyrimidine-2-Carboxylic Acid adheres to a stringent quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis by GC. We provide detailed Certificates of Analysis (COA) with each shipment, ensuring full traceability and compliance with your research or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.