Description

Furo[2,3-D]Pyrimidine-6-Carboxamide, 3-[(3,4-Difluorophenyl)Methyl]-1,2,3,4-Tetrahydro-n-[(2-Methoxy-4-Pyridinyl)Methyl]-1-Methyl-2-Oxo- is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is of significant value for its role as a key building block in the research and development of novel therapeutic agents, particularly in kinase inhibitor programs. It is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of targeted small-molecule drugs. The precise molecular architecture offers a critical scaffold for modulating biological activity in drug discovery pipelines.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of investigational new drugs (INDs) and new chemical entities (NCEs).
• Kinase Inhibitor Development: Used as a core scaffold in the research and development of potent and selective kinase inhibitors for oncology and inflammatory diseases.
• Medicinal Chemistry Research: Provides a versatile template for structure-activity relationship (SAR) studies and lead optimization in drug discovery projects.
• Biochemical Tool Compound: Can be utilized in the development of assay probes and tool molecules for target validation and biological pathway analysis.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP or research-grade conditions.
• Academic Research: Employed in university and institutional laboratories for fundamental research in organic synthesis and chemical biology.

Basic Information

Product Name	Furo[2,3-D]Pyrimidine-6-Carboxamide, 3-[(3,4-Difluorophenyl)Methyl]-1,2,3,4-Tetrahydro-n-[(2-Methoxy-4-Pyridinyl)Methyl]-1-Methyl-2-Oxo-
CAS No.	660819-04-5
Molecular Formula	C24H24F2N4O3
Molecular Weight	454.47 g/mol
Synonyms	3-[(3,4-Difluorophenyl)methyl]-1,2,3,4-tetrahydro-N-[(2-methoxy-4-pyridinyl)methyl]-1-methyl-2-oxofuro[2,3-d]pyrimidine-6-carboxamide; Furo[2,3-d]pyrimidine-6-carboxamide, 3-[(3,4-difluorophenyl)methyl]-1,2,3,4-tetrahydro-N-[(2-methoxy-4-pyridinyl)methyl]-1-methyl-2-oxo-; 660819-04-5; UNII-7Q0J8QZ1B9; 7Q0J8QZ1B9; SCHEMBL218042; AKOS025310626; ZINC000103430511
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols to ensure batch-to-batch consistency and purity suitable for research and development applications. Standard quality assurance includes comprehensive analytical characterization using HPLC, NMR, and MS. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles. We support development projects with custom synthesis and analytical method development upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified for long-term storage.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.