Description

4-Chloro-6-(4'-(Trifluoromethyl)Phenyl)Pyrimidine is a high-value, multi-functional heterocyclic building block essential for advanced organic synthesis. Its core value lies in the strategic combination of a reactive chloropyrimidine group and a stable, electron-deficient trifluoromethylphenyl moiety, enabling precise molecular construction. This compound is critically needed by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of kinase inhibitors, antiviral agents, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in constructing advanced fungicides, herbicides, and plant growth regulators leveraging the CF3 group for enhanced bioactivity and metabolic stability.
• Material Science Research: Serves as a precursor for organic electronic materials, such as ligands for OLEDs or molecular semiconductors.
• Cross-Coupling Reactions: The chloro substituent makes it an excellent substrate for Suzuki, Buchwald-Hartwig, and other palladium-catalyzed cross-coupling reactions.
• Chemical Biology Probes: Utilized in designing activity-based probes and molecular tags for studying biological systems.
• Custom Synthesis & Contract Manufacturing: A fundamental building block for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	4-Chloro-6-(4'-(Trifluoromethyl)Phenyl)Pyrimidine
CAS No.	659729-09-6
Molecular Formula	C11H6ClF3N2
Molecular Weight	258.62 g/mol
Synonyms	4-Chloro-6-[4-(trifluoromethyl)phenyl]pyrimidine; 6-(4-(Trifluoromethyl)phenyl)pyrimidin-4-yl chloride; 4-Chloro-6-(4-trifluoromethylphenyl)pyrimidine; 4-Chloro-6-(alpha,alpha,α-trifluoro-p-tolyl)pyrimidine; 4-Chloro-6-(p-trifluoromethylphenyl)pyrimidine; 659729-09-6; 4-Chloro-6-(4'-(trifluoromethyl)phenyl)pyrimidine
EINECS	Contact for details

Quality Control

Every batch of 4-Chloro-6-(4'-(Trifluoromethyl)Phenyl)Pyrimidine undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality commitment includes adherence to in-house specifications developed for fine chemical and pharmaceutical intermediate applications. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.