Description

4-Chloro-Thieno[2,3-D]Pyrimidine-6-Carboxylic Acid Methyl Ester is a high-value heterocyclic building block and advanced pharmaceutical intermediate. This compound is critical for medicinal chemistry research and the synthesis of novel active pharmaceutical ingredients (APIs) targeting a range of therapeutic areas. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries.

Application

• Pharmaceutical Intermediate: A key synthon for the development of kinase inhibitors and other small molecule therapeutics.
• Medicinal Chemistry Research: Used in high-throughput screening and structure-activity relationship (SAR) studies for drug discovery programs.
• Agrochemical Synthesis: Serves as a precursor in the creation of novel herbicides and fungicides with thienopyrimidine cores.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological pathways.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up production under cGMP conditions.
• Academic Research: Used in university and institutional labs for heterocyclic chemistry and methodology development.

Basic Information

Product Name	4-Chloro-Thieno[2,3-D]Pyrimidine-6-Carboxylic Acid Methyl Ester
CAS No.	655253-69-3
Molecular Formula	C8H5ClN2O2S
Molecular Weight	228.65 g/mol
Synonyms	Methyl 4-chlorothieno[2,3-d]pyrimidine-6-carboxylate; 4-Chloro-6-(methoxycarbonyl)thieno[2,3-d]pyrimidine; Thieno[2,3-d]pyrimidine-6-carboxylic acid, 4-chloro-, methyl ester; 655253-69-3; 4-Chloro-thieno[2,3-d]pyrimidine-6-carboxylic acid methyl ester; Methyl 4-chloro-thieno[2,3-d]pyrimidine-6-carboxylate
EINECS	Contact for details

Quality Control

Our 4-Chloro-Thieno[2,3-D]Pyrimidine-6-Carboxylic Acid Methyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.