Description

4,6-Dichloro-2-[(2,3-Difluorobenzyl)Thio]Pyrimidine (Wxg00547) is a high-purity, multi-functional pyrimidine derivative, identified by CAS No. 654073-29-7, serving as a critical advanced intermediate in modern synthetic chemistry. Its value lies in its unique molecular scaffold, which combines halogenated and fluorinated benzylthio substituents, making it an essential building block for constructing complex molecules with targeted biological activity. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in antiviral, anticancer, and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, leveraging its halogenated pyrimidine core.
• Material Science Research: Serves as a precursor for synthesizing specialized polymers, ligands, or organic electronic materials.
• Chemical Biology & Proteomics: Employed as a molecular probe or a tagging reagent in biochemical studies and target identification.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and GMP production.
• Academic Research: Utilized in university and institutional labs for methodological development in organic and medicinal chemistry.

Basic Information

Product Name	4,6-Dichloro-2-[(2,3-Difluorobenzyl)Thio]Pyrimidine (Wxg00547)
CAS No.	654073-29-7
Molecular Formula	C11H6Cl2F2N2S
Molecular Weight	307.15 g/mol
Synonyms	2-[(2,3-Difluorobenzyl)thio]-4,6-dichloropyrimidine; 4,6-Dichloro-2-((2,3-difluorobenzyl)thio)pyrimidine; WXG00547; 654073-29-7; 2-(2,3-Difluorobenzylsulfanyl)-4,6-dichloropyrimidine; 4,6-Dichloro-2-(2,3-difluorobenzylthio)pyrimidine; Pyrimidine, 4,6-dichloro-2-[(2,3-difluorophenyl)methyl]thio]-
EINECS	Contact for details

Quality Control

Our 4,6-Dichloro-2-[(2,3-Difluorobenzyl)Thio]Pyrimidine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, NMR, and MS, to verify identity and purity against established specifications. Certificates of Analysis (COA) are provided with every shipment, detailing all critical quality attributes. We support compliance with relevant guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.