Description

Methyl n-(Benzyloxycarbonyl)Valyl-D-Alloisoleucylthreonylnorvalinate is a synthetic peptide derivative primarily used as a key intermediate in advanced pharmaceutical research and development. This compound is critical for the synthesis of complex peptide-based drug candidates, enabling precise control over molecular structure and biological activity. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors focused on developing novel therapeutics, particularly in the fields of oncology, metabolic disorders, and infectious diseases.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel peptide-based active pharmaceutical ingredients (APIs).
• Drug Discovery & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Protease Inhibitor Research: Serves as a substrate or inhibitor analog in biochemical assays to study enzyme mechanisms.
• Peptide Library Synthesis: Employed in combinatorial chemistry to create diverse peptide libraries for high-throughput screening.
• Bioconjugation: Acts as a linker or spacer molecule in the development of peptide-drug conjugates (PDCs) and other bioconjugates.
• Academic & Contract Research: Utilized in university and CRO laboratories for fundamental research in peptide science and biochemistry.

Basic Information

Product Name	Methyl n-(Benzyloxycarbonyl)Valyl-D-Alloisoleucylthreonylnorvalinate
CAS No.	653574-13-1
Molecular Formula	C30H46N4O8
Molecular Weight	590.71 g/mol
Synonyms	Z-Val-D-alloIle-Thr-Nva-OMe; Methyl N-[(benzyloxy)carbonyl]-L-valyl-D-alloisoleucyl-L-threonyl-L-norvalinate; Cbz-Val-D-alloIle-Thr-Nva-OMe; Benzyloxycarbonyl-Val-D-alloisoleucyl-Thr-norvaline Methyl Ester; (3S,6S,9R,12S)-9-Benzyl-3-[(2S)-2-[[(benzyloxy)carbonyl]amino]-3-methylbutyl]-12-[(1S)-1-methylpropyl]-6-(1-hydroxyethyl)-2,5,8,11-tetraoxo-1,4,7,10-tetrazacyclododecane-13-carboxylic acid methyl ester (cyclic form); Z-Val-D-aIle-Thr-Nva-OMe; Peptide Synthesis Intermediate 653574-13-1
EINECS	Contact for details

Quality Control

Our Methyl n-(Benzyloxycarbonyl)Valyl-D-Alloisoleucylthreonylnorvalinate is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to ensure stereochemical integrity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality ensures material suitable for advanced research and pre-clinical development under cGMP-like controls where required.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to warm to room temperature before opening to minimize condensation and moisture uptake. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Chiral Purity (HPLC)	≥ 99.0% ee

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.