Description

[4-Chloro-2-(Trifluoromethyl)Phenyl]Amine Hydrochloride is a high-purity, halogenated aniline derivative salt, serving as a critical building block in advanced organic synthesis. Its value lies in the unique combination of chloro and trifluoromethyl substituents, which are essential for modulating the electronic and steric properties of target molecules. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and infectious diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Material Science Research: Serves as a monomer or functionalizing agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Dye and Pigment Manufacturing: Acts as an intermediate for producing complex, high-performance dyes and pigments with specific color fastness and solubility properties.
• Cross-Coupling Reactions: An essential substrate in palladium-catalyzed reactions like Buchwald-Hartwig amination for constructing complex nitrogen-containing heterocycles.

Basic Information

Product Name	[4-Chloro-2-(Trifluoromethyl)Phenyl]Amine Hydrochloride
CAS No.	648415-76-3
Molecular Formula	C7H6ClF3N·HCl
Molecular Weight	246.49 g/mol
Synonyms	4-Chloro-2-(trifluoromethyl)aniline hydrochloride; 2-Amino-5-chlorobenzotrifluoride hydrochloride; 5-Chloro-α,α,α-trifluoro-o-toluidine hydrochloride; 4-Chloro-α,α,α-trifluoro-o-toluidine hydrochloride; 2-Trifluoromethyl-4-chloroaniline hydrochloride; 4-Chloro-2-trifluoromethylphenylamine hydrochloride; 648415-76-3; 4-Chloro-2-(trifluoromethyl)benzenamine hydrochloride
EINECS	Contact for details

Quality Control

Our [4-Chloro-2-(Trifluoromethyl)Phenyl]Amine Hydrochloride is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) documenting all critical parameters are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.