Description

4-Chloro-2-(Trifluoromethyl)-5,6,7,8-Tetrahydropyrido[3,4-D]Pyrimidine is a high-value, heterocyclic building block featuring a fused pyrido-pyrimidine core with chloro and trifluoromethyl substituents. This compound is critical for medicinal chemistry research and development, offering a versatile scaffold for creating novel bioactive molecules. It is primarily sought by pharmaceutical R&D teams and fine chemical manufacturers engaged in the synthesis of potential drug candidates, particularly in oncology and CNS therapeutic areas.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the development of novel small-molecule drug candidates.
• Medicinal Chemistry Research: Used as a privileged scaffold for structure-activity relationship (SAR) studies and library synthesis.
• Kinase Inhibitor Development: The pyrido[3,4-d]pyrimidine core is a common motif in the design of protein kinase inhibitors.
• Agrochemical Research: Employed in the synthesis of new active ingredients for crop protection products.
• Chemical Biology Probes: Utilized to create tool compounds for investigating biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of complex molecules under cGMP or research-grade conditions.

Basic Information

Product Name	4-Chloro-2-(Trifluoromethyl)-5,6,7,8-Tetrahydropyrido[3,4-D]Pyrimidine
CAS No.	647863-08-9
Molecular Formula	C9H7ClF3N3
Molecular Weight	249.62 g/mol
Synonyms	4-Chloro-2-(trifluoromethyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine; 5,6,7,8-Tetrahydro-4-chloro-2-(trifluoromethyl)pyrido[3,4-d]pyrimidine; 4-Chloro-2-trifluoromethyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine; 647863-08-9; Pyrido[3,4-d]pyrimidine, 4-chloro-5,6,7,8-tetrahydro-2-(trifluoromethyl)-; 4-Chloro-2-(trifluoromethyl)-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidine
EINECS	Contact for details

Quality Control

Our 4-Chloro-2-(Trifluoromethyl)-5,6,7,8-Tetrahydropyrido[3,4-D]Pyrimidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure consistency and compliance with research and development standards. Certificates of Analysis (COA) detailing all specifications are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.