Description

n-Fmoc-L-Homoserine Benzyl Ester is a protected amino acid derivative of significant importance in modern organic synthesis. This compound serves as a crucial building block for the solid-phase and solution-phase synthesis of peptides and peptidomimetics, offering orthogonal protection for the side-chain hydroxyl group. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in developing novel therapeutic peptides, bioactive probes, and complex natural products.

Application

• Peptide Synthesis: A key protected intermediate for the incorporation of L-homoserine into peptide chains during Fmoc-based solid-phase peptide synthesis (SPPS).
• Pharmaceutical Research: Used in the development and production of peptide-based drug candidates, hormone analogs, and enzyme inhibitors.
• Bioconjugation: Serves as a precursor for creating linkers or modified amino acids used in antibody-drug conjugates (ADCs) and other bioconjugation strategies.
• Chemical Biology: Employed in the synthesis of labeled peptides, activity-based probes, and tools for studying protein-protein interactions.
• Material Science: Can be used to synthesize peptide-polymer hybrids or surface-modifying agents.

Basic Information

Product Name	n-Fmoc-L-Homoserine Benzyl Ester
CAS No.	647847-95-8
Molecular Formula	C26H25NO5
Molecular Weight	431.48 g/mol
Synonyms	Fmoc-Homoserine(OBzl)-OH; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-4-(phenylmethoxy)butanoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-homoserine benzyl ester; L-Homoserine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, 4-(phenylmethyl) ester; Fmoc-Hse(OBzl)-OH; Fmoc-L-Homoserine benzyl ester; N-α-Fmoc-L-homoserine O-benzyl ester
EINECS	Contact for details

Quality Control

Our n-Fmoc-L-Homoserine Benzyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation (IR, NMR) to ensure it meets the high standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistent quality for your research and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Optical Rotation	-15.0° to -18.0° (c=1 in DMF)
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.