Description

3,4,5-Trifluoro-L-Phenylalanine is a fluorinated derivative of the essential amino acid L-phenylalanine, distinguished by its unique trifluoromethyl substitution pattern. This structural modification is critical for enhancing metabolic stability, lipophilicity, and binding affinity in advanced pharmaceutical research and development. It serves as a key chiral building block and intermediate for medicinal chemists and researchers in the life sciences sector, particularly in the synthesis of novel active pharmaceutical ingredients (APIs), peptide-based therapeutics, and positron emission tomography (PET) tracers.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the research and development of novel drug candidates, especially in oncology and central nervous system (CNS) disorders.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate fluorinated amino acids, modifying the stability and bioavailability of therapeutic peptides.
• Proteomics & Biochemical Research: Employed as a non-natural amino acid in studies of protein structure, function, and enzyme-substrate interactions.
• PET (Positron Emission Tomography) Tracer Development: Acts as a precursor for fluorine-18 labeled compounds used in diagnostic imaging.
• Agrochemical Research: Serves as an intermediate in the design of new pesticides and herbicides, leveraging the properties of fluorine atoms.
• Material Science: Potential building block for advanced polymers and functional materials with specific electronic or surface properties.

Basic Information

Product Name	3,4,5-Trifluoro-L-Phenylalanine
CAS No.	646066-73-1
Molecular Formula	C9H8F3NO2
Molecular Weight	219.16 g/mol
Synonyms	L-3,4,5-Trifluorophenylalanine; (S)-2-Amino-3-(3,4,5-trifluorophenyl)propanoic acid; 3,4,5-Trifluoro-DL-phenylalanine (related); F3Phe; 3,4,5-Trifluoro Phe; 3,4,5-Trifluorophenylalanine; TFP; NSC 760463
EINECS	Contact for details

Quality Control

Our 3,4,5-Trifluoro-L-Phenylalanine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-Isomer)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.