Description

Val-Cit-Pab-Mmae is a specialized, high-purity chemical linker used in the synthesis of antibody-drug conjugates (ADCs). This compound matters for its critical role in creating stable, targeted cancer therapeutics by enabling the controlled release of potent cytotoxic payloads. Pharmaceutical researchers and bioconjugation specialists need this advanced intermediate to develop next-generation oncology treatments with improved efficacy and safety profiles.

Application

• Antibody-Drug Conjugate (ADC) Synthesis: As a key cleavable linker for attaching cytotoxic drugs (e.g., MMAE) to monoclonal antibodies.
• Targeted Cancer Therapy Development: Enabling the creation of precision medicines designed to selectively deliver chemotherapeutic agents to tumor cells.
• Bioconjugation Research: Serving as a critical reagent in R&D for novel drug delivery systems and targeted biologics.
• Prodrug Design: Used in the development of prodrugs that are activated by specific enzymes (e.g., cathepsin B) in the tumor microenvironment.
• Pharmaceutical Intermediate: A high-value building block in the multi-step synthesis of complex therapeutic molecules.

Basic Information

Product Name	Val-Cit-Pab-Mmae
CAS No.	644981-35-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Valine-Citrulline-PAB-MMAE; VC-PAB-MMAE; Maleimidocaproyl-valyl-citrullinyl-p-aminobenzyloxycarbonyl-MMAE; MC-VC-PAB-MMAE; ADC Linker VC-PAB-MMAE; Cleavable Linker for ADCs; Val-Cit-PAB-Monomethyl Auristatin E; Enzyme-cleavable ADC linker
EINECS	Contact for details

Quality Control

Our Val-Cit-Pab-Mmae is manufactured under strict quality systems suitable for pharmaceutical R&D. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure consistency and reliability. Certificates of Analysis (COA) with detailed specifications are provided to support your regulatory and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, inert environment. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.