Description

2-Chloro-4-(m-Tolylamino)Pyrimidine-5-Carboxamide is a high-purity, advanced pharmaceutical intermediate characterized by its specific pyrimidine-based molecular structure. This compound is of critical importance for research and development in medicinal chemistry, serving as a key building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily needed by pharmaceutical manufacturers, biotechnology R&D laboratories, and fine chemical synthesis companies focused on developing new therapeutic agents.

Application

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of potential drug candidates, particularly in oncology and antiviral research.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes to develop new molecular entities.
• Kinase Inhibitor Development: Serves as a core scaffold for the research and synthesis of protein kinase inhibitors, a major class of targeted cancer therapies.
• Custom Synthesis: Employed by fine chemical suppliers for the contract manufacturing of specialized, non-commercial compounds for client R&D projects.
• Academic Research: Utilized in university and institutional laboratories for studies in organic synthesis methodologies and heterocyclic chemistry.

Basic Information

Product Name	2-Chloro-4-(m-Tolylamino)Pyrimidine-5-Carboxamide
CAS No.	643087-03-0
Molecular Formula	C12H11ClN4O
Molecular Weight	262.70 g/mol
Synonyms	2-Chloro-4-[(3-methylphenyl)amino]-5-pyrimidinecarboxamide; 2-Chloro-4-(3-methylanilino)pyrimidine-5-carboxamide; 5-Carbamoyl-2-chloro-4-(m-tolylamino)pyrimidine; 643087-03-0; 2-Chloro-4-(3-methylphenylamino)pyrimidine-5-carboxylic acid amide; N-(3-Methylphenyl)-2-chloropyrimidine-4,5-dicarboximide (related); m-Tolylamino pyrimidine carboxamide derivative
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-(m-Tolylamino)Pyrimidine-5-Carboxamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (typically 15-25°C). This material is likely light-sensitive and should be stored away from direct light exposure. Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.