Description

(E)-3-(Dimethylamino)-1-(Pyrimidin-5-Yl)Prop-2-En-1-One is a high-purity, advanced pharmaceutical intermediate characterized by its chalcone-like structure. This compound is of significant commercial value as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs) and other fine chemicals. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing novel therapeutic agents and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of kinase inhibitors and other targeted small-molecule drugs.
• Agrochemical Research: Used in the development of new pesticides and herbicides, leveraging its heterocyclic framework.
• Chemical Synthesis: Acts as a versatile Michael acceptor or donor in organic synthesis for constructing complex molecular architectures.
• Material Science: Investigated as a monomer or precursor for functional polymers and organic electronic materials.
• Bioconjugation: Potential use in linker chemistry for antibody-drug conjugates (ADCs) due to its reactive enone moiety.
• Academic & R&D: Employed in medicinal chemistry programs for structure-activity relationship (SAR) studies and hit-to-lead optimization.

Basic Information

Product Name	(E)-3-(Dimethylamino)-1-(Pyrimidin-5-Yl)Prop-2-En-1-One
CAS No.	641615-34-1
Molecular Formula	C9H11N3O
Molecular Weight	177.20 g/mol
Synonyms	(E)-3-(Dimethylamino)-1-(5-pyrimidinyl)-2-propen-1-one; 3-(Dimethylamino)-1-(pyrimidin-5-yl)prop-2-en-1-one; (E)-3-(Dimethylamino)-1-(pyrimidin-5-yl)prop-2-en-1-one; 5-[(1E)-3-(Dimethylamino)-1-oxo-2-propen-1-yl]pyrimidine; (E)-1-(Pyrimidin-5-yl)-3-(dimethylamino)prop-2-en-1-one; NSC 797887; Chalcone derivative, Pyrimidinyl enaminone
EINECS	Contact for details

Quality Control

Our (E)-3-(Dimethylamino)-1-(Pyrimidin-5-Yl)Prop-2-En-1-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider inert gas purging to maintain stability.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.