Description

4-Phenyl-3-(Trifluoromethyl)Aniline is a specialized aromatic amine building block featuring a phenyl substituent and a trifluoromethyl group on the aniline core. This compound matters for its unique structural motif, which combines the electronic and steric properties of the trifluoromethyl group with the versatility of an aniline derivative, making it a valuable intermediate in advanced synthesis. It is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients, as well as by manufacturers of specialty materials and dyes.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the trifluoromethyl group can enhance biological activity and metabolic stability.
• Material Science: Serves as a precursor for functional polymers, liquid crystals, and organic electronic materials due to its aromatic and electron-withdrawing characteristics.
• Dye and Pigment Manufacturing: Acts as an intermediate in the production of specialized dyes and pigments, contributing to color fastness and unique optical properties.
• Chemical Research: Employed in academic and industrial R&D for method development, catalysis studies, and exploring structure-activity relationships (SAR).
• Cross-Coupling Reactions: Utilized as a substrate in palladium-catalyzed reactions (e.g., Buchwald-Hartwig amination) to create complex biaryl amine structures.

Basic Information

Product Name	4-Phenyl-3-(Trifluoromethyl)Aniline
CAS No.	641570-82-3
Molecular Formula	C13H10F3N
Molecular Weight	237.22 g/mol
Synonyms	3-(Trifluoromethyl)-4-phenylaniline; 4-Phenyl-3-(trifluoromethyl)benzenamine; Benzenamine, 4-phenyl-3-(trifluoromethyl)-; 3-Trifluoromethyl-4-phenylaniline; 4-Phenyl-alpha,alpha,α-trifluoro-m-toluidine; [1,1'-Biphenyl]-3-amine, 4'-(trifluoromethyl)-; 4'-Amino-2-(trifluoromethyl)biphenyl
EINECS	Contact for details

Quality Control

Our 4-Phenyl-3-(Trifluoromethyl)Aniline is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for advanced organic synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee supply reliability and technical compliance for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in the original packaging or amber glass until use.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.