Description

1-Azetidinesulfonyl Chloride is a versatile and highly reactive sulfonyl chloride derivative of azetidine, serving as a critical building block in advanced organic synthesis. Its value lies in its ability to introduce the strained, nitrogen-containing azetidine ring system while providing a reactive handle for further functionalization via the sulfonyl chloride group. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries who are developing novel active ingredients, particularly for creating sulfonamide-based compounds with potential biological activity.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those containing sulfonamide pharmacophores for therapeutic areas like oncology, neurology, and infectious diseases.
• Agrochemical Research: Used in developing new herbicides, fungicides, and insecticides by incorporating the azetidine moiety to modulate biological activity and physicochemical properties.
• Chemical Biology Probe Development: Employed to create activity-based probes (ABPs) or affinity labels for studying enzyme function and target identification due to its reactive sulfonyl chloride group.
• Material Science: Potential monomer or cross-linking agent for creating polymers with unique properties derived from the strained four-membered azetidine ring.
• Custom Synthesis & Contract Manufacturing: Serves as a specialized starting material for custom synthesis projects and scale-up processes in fine chemical production.
• Sulfonamide Library Synthesis: Facilitates high-throughput parallel synthesis for creating diverse sulfonamide compound libraries for screening in drug discovery programs.

Basic Information

Product Name	1-Azetidinesulfonyl Chloride
CAS No.	639519-67-8
Molecular Formula	C3H6ClNO2S
Molecular Weight	155.60 g/mol
Synonyms	Azetidine-1-sulfonyl chloride; Azetidine-1-sulfonylchloride; 1-Sulfonylchlorideazetidine; Azetidine, 1-(chlorosulfonyl)-; Azetidin-1-ylsulfonyl chloride; Azetidine sulfonyl chloride; 1-(Chlorosulfonyl)azetidine
EINECS	Contact for details

Quality Control

Our 1-Azetidinesulfonyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development. We employ advanced analytical techniques including HPLC, GC, NMR, and IR spectroscopy for comprehensive characterization. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.