Description

n-(4-(4-(3-Methyl-1H-Pyrazol-5-Ylamino)-6-(4-Methylpiperazin-1-Yl)Pyrimidin-2-Ylthio)Phenyl)Propionamide CAS NO 639089-73-9 is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is valued for its role as a critical building block in the synthesis of targeted therapeutic agents, offering precise molecular architecture essential for modern drug discovery. It is primarily required by R&D laboratories and production facilities in the pharmaceutical and biotechnology sectors for developing novel small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel kinase inhibitors and other targeted cancer therapies.
• Biochemical Research: Used as a reference standard or a building block in medicinal chemistry programs for structure-activity relationship (SAR) studies.
• API Development: Serves as a core structural component in the development and scale-up of new Active Pharmaceutical Ingredients (APIs).
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.
• Academic Research: Utilized in university and institutional labs for investigating new pharmacological pathways and mechanisms of action.

Basic Information

Item	Details
Product Name	n-(4-(4-(3-Methyl-1H-Pyrazol-5-Ylamino)-6-(4-Methylpiperazin-1-Yl)Pyrimidin-2-Ylthio)Phenyl)Propionamide
CAS No.	639089-73-9
Molecular Formula	C22H28N8OS
Molecular Weight	452.58 g/mol
Synonyms	N-[4-[[4-[(5-Amino-3-methyl-1H-pyrazol-1-yl)]-6-(4-methyl-1-piperazinyl)-2-pyrimidinyl]thio]phenyl]propionamide; 639089-73-9; UNII-6Q9Y1S6K6F; Propionamide, N-[4-[[4-[(5-amino-3-methyl-1H-pyrazol-1-yl)]-6-(4-methyl-1-piperazinyl)-2-pyrimidinyl]thio]phenyl]-; 6Q9Y1S6K6F; BDBM50391425; AKOS025310584; ZINC000003869949
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity. Quality is verified through a comprehensive suite of analytical techniques including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.