Description

2-(Methylsulfonyl)-4-(Pyridin-3-Yl) Pyrimidine is a high-purity, advanced pharmaceutical intermediate characterized by its distinct pyrimidine core functionalized with a methylsulfonyl group and a pyridinyl substituent. This compound is critical for the synthesis of targeted small-molecule therapeutics, particularly kinase inhibitors, due to its role as a key building block that imparts specific binding and pharmacokinetic properties. It is primarily required by pharmaceutical R&D departments, contract research/manufacturing organizations (CROs/CMOs), and fine chemical producers engaged in the development of novel oncology and anti-inflammatory drugs.

Application

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of novel kinase inhibitors for oncology and inflammatory disease research.
• Biochemical Research: Used as a reference standard or a probe molecule in enzymatic assays and structure-activity relationship (SAR) studies.
• Preclinical Development: Serves as a key starting material (KSM) or an advanced intermediate for producing active pharmaceutical ingredients (APIs) in gram to kilogram scales for preclinical trials.
• Chemical Biology: Employed in the design and synthesis of chemical tools for target identification and validation in cellular pathways.
• Custom Synthesis: Utilized by fine chemical suppliers for the custom manufacturing of complex, target-specific molecules for client projects.

Basic Information

Product Name	2-(Methylsulfonyl)-4-(Pyridin-3-Yl) Pyrimidine
CAS No.	637354-25-7
Molecular Formula	C10H9N3O2S
Molecular Weight	235.26 g/mol
Synonyms	4-(3-Pyridinyl)-2-(methylsulfonyl)pyrimidine; 2-Methylsulfonyl-4-(3-pyridyl)pyrimidine; 4-(Pyridin-3-yl)-2-(methylsulfonyl)pyrimidine; 637354-25-7; Pyrimidine, 2-(methylsulfonyl)-4-(3-pyridinyl)-; 2-(Methanesulfonyl)-4-(pyridin-3-yl)pyrimidine
EINECS	Contact for details

Quality Control

Our 2-(Methylsulfonyl)-4-(Pyridin-3-Yl) Pyrimidine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our production adheres to cGMP guidelines where applicable, ensuring the material meets the stringent requirements for pharmaceutical R&D and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) in the original packaging to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.