Description

4(3H)-Quinazolinone, 8-Hydroxy-2-(Phenylmethyl)-3-[4-[2,2,2-Trifluoro-1-Hydroxy-1-(Trifluoromethyl)Ethyl]Phenyl]- is a high-value, multifunctional heterocyclic compound featuring a quinazolinone core substituted with hydroxy, benzyl, and a unique trifluoromethyl carbinol-containing phenyl group. This molecular architecture makes it a critical advanced pharmaceutical intermediate and a versatile scaffold for medicinal chemistry research. It is primarily sought after by R&D and production teams in the pharmaceutical, agrochemical, and advanced material sectors for developing novel active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of potential drug candidates, particularly for central nervous system (CNS) and oncology targets.
• Medicinal Chemistry Research: Used as a privileged scaffold for structure-activity relationship (SAR) studies and library synthesis due to its hydrogen-bonding capacity and lipophilic character.
• Agrochemical Development: Acts as a precursor for novel herbicides, fungicides, or insecticides, leveraging the biological activity of the quinazolinone moiety.
• Biochemical Probe Synthesis: Utilized in creating labeled compounds or probes for studying enzyme inhibition and biological pathways.
• Material Science Research: Investigated for its potential in creating specialty polymers or organic electronic materials due to its conjugated system and functional groups.

Basic Information

Item	Details
Product Name	4(3H)-Quinazolinone, 8-Hydroxy-2-(Phenylmethyl)-3-[4-[2,2,2-Trifluoro-1-Hydroxy-1-(Trifluoromethyl)Ethyl]Phenyl]-
CAS No.	637345-58-5
Molecular Formula	C25H18F6N2O2
Molecular Weight	492.42 g/mol
Synonyms	8-Hydroxy-2-benzyl-3-[4-(1-hydroxy-2,2,2-trifluoro-1-trifluoromethyl-ethyl)phenyl]-4(3H)-quinazolinone; 2-Benzyl-8-hydroxy-3-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4(3H)-quinazolinone; 8-Hydroxy-2-(phenylmethyl)-3-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4(3H)-quinazolinone; BCTC (analog-related); Trifluoromethyl carbinol-substituted quinazolinone; A-967079 (structural analog)
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management protocols to ensure batch-to-batch consistency and high purity. Quality is verified through a comprehensive suite of analytical techniques including HPLC, NMR, and MS. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment. We support development projects with custom purity grades, from research (≥95%) to preclinical (≥98%) standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 95.0% (Research Grade) ≥ 98.0% (Preclinical Grade)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.