Description

tert-Butyl 2,4-Dichloro-7,8-Dihydropyrido[4,3-D]Pyrimidine-6(5H)-Carboxylate is a high-purity, advanced pharmaceutical intermediate belonging to the pyridopyrimidine class of heterocyclic compounds. This compound is a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting kinase inhibition. It is essential for research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, where precise chemical structure and reliable purity are paramount for successful outcomes.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the multi-step production of targeted kinase inhibitors and other small-molecule drugs.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new chemical entities with potential therapeutic value.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs for the custom synthesis of client-specific API candidates and development compounds.
• Oncology Drug Discovery: A vital scaffold in the research pipeline for novel anti-cancer treatments due to the pyridopyrimidine core's relevance in oncology targets.

Basic Information

Product Name	tert-Butyl 2,4-Dichloro-7,8-Dihydropyrido[4,3-D]Pyrimidine-6(5H)-Carboxylate
CAS No.	635698-56-5
Molecular Formula	C16H18Cl2N3O2
Molecular Weight	355.24 g/mol
Synonyms	6-tert-Butoxycarbonyl-2,4-dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine; 2,4-Dichloro-6-[(2-methylpropan-2-yl)oxycarbonyl]-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine; tert-Butyl 2,4-dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-6-carboxylate; 2,4-Dichloro-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxylic acid tert-butyl ester; BOC-protected 2,4-dichlorotetrahydropyridopyrimidine
EINECS	Contact for details

Quality Control

Our tert-Butyl 2,4-Dichloro-7,8-Dihydropyrido[4,3-D]Pyrimidine-6(5H)-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D and cGMP intermediate applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for full traceability and quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.