Description

4-Chloro-2-Piperazin-1-Yl-Pyrimidine Hydrochloride is a high-purity, pharmaceutically relevant chemical intermediate. This compound matters for its critical role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in kinase inhibitor research and development. It is primarily needed by pharmaceutical R&D laboratories, contract research/manufacturing organizations (CROs/CMOs), and fine chemical producers engaged in the development of novel therapeutics.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of kinase inhibitors and other targeted small-molecule therapeutics.
• Chemical Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Academic Research: Employed in biochemical and pharmacological studies investigating specific enzymatic pathways.
• Custom Synthesis: Serves as a starting material for the contract manufacturing of proprietary drug candidates and reference standards.
• Process Chemistry: Utilized in the scale-up and optimization of synthetic routes for potential commercial API production.

Basic Information

Product Name	4-Chloro-2-Piperazin-1-Yl-Pyrimidine Hydrochloride
CAS No.	634469-41-3
Molecular Formula	C8H12ClN5•HCl
Molecular Weight	266.58 g/mol
Synonyms	4-Chloro-2-(piperazin-1-yl)pyrimidine hydrochloride; 2-(1-Piperazinyl)-4-chloropyrimidine hydrochloride; 4-Chloro-2-piperazin-1-ylpyrimidine HCl; 4-Chloro-2-(1-piperazinyl)pyrimidine monohydrochloride; 634469-41-3; 4-Chloro-2-piperazinylpyrimidine hydrochloride
EINECS	Contact for details

Quality Control

Our 4-Chloro-2-Piperazin-1-Yl-Pyrimidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) documenting all critical quality attributes are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.