Description

4-(Piperazin-1-yl)pyrimidine dihydrochloride is a high-purity, versatile pharmaceutical intermediate and building block. Its value lies in its role as a key synthon for constructing complex molecules with piperazine and pyrimidine pharmacophores, which are prevalent in active pharmaceutical ingredients. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries engaged in drug discovery, process development, and custom synthesis.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of kinase inhibitors, receptor antagonists, and other bioactive molecules targeting various therapeutic areas.
• Drug Discovery & Medicinal Chemistry: Used in high-throughput screening libraries and for constructing novel chemical entities in lead optimization and structure-activity relationship (SAR) studies.
• Agrochemical Research: Serves as a precursor in the development of new herbicides, fungicides, and insecticides that incorporate heterocyclic amine structures.
• Chemical Biology & Biochemical Tools: Employed in the design and synthesis of molecular probes, enzyme inhibitors, and labeled compounds for biological research.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis projects requiring specific, high-purity heterocyclic amine salts.
• Academic Research: Used in universities and research institutes for methodological development in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	4-(Piperazin-1-yl)pyrimidine dihydrochloride
CAS No.	634468-72-7
Molecular Formula	C8H14Cl2N4
Molecular Weight	237.13 g/mol
Synonyms	4-(1-Piperazinyl)pyrimidine dihydrochloride; Pyrimidine, 4-(1-piperazinyl)-, dihydrochloride; 4-Piperazin-1-ylpyrimidine dihydrochloride; 4-Pyrimidinamine, N-(1-piperazinyl)-, dihydrochloride; 1-(Pyrimidin-4-yl)piperazine dihydrochloride; 4-(Piperazin-1-yl)pyrimidine hydrochloride (1:2); 4-Piperazinylpyrimidine dihydrochloride
EINECS	Contact for details

Quality Control

Our 4-(Piperazin-1-yl)pyrimidine dihydrochloride is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting critical parameters such as assay, impurity profile, and residual solvents. Our quality commitment supports applications requiring GMP-grade starting materials and research-grade chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.