Description

β-Amyloid (33-40) is a specific peptide fragment derived from the amyloid precursor protein (APP), a key molecule in Alzheimer's disease research. This octapeptide sequence is critical for studying the aggregation mechanisms, neurotoxicity, and structural properties of amyloid beta proteins. It serves as an essential biochemical tool for researchers and developers in the fields of neuroscience, diagnostics, and therapeutic discovery. This high-purity synthetic peptide is designed for demanding applications requiring precise molecular characterization and reliable performance.

Application

• Biochemical Research: Fundamental studies on amyloid beta peptide aggregation kinetics, fibril formation, and structure-activity relationships.
• Neuroscience & Alzheimer's Disease Models: Used to induce and study neurotoxicity in cellular and animal models of Alzheimer's disease.
• Diagnostic Assay Development: A key antigen or standard for developing immunoassays (ELISA) and other detection methods targeting amyloid beta fragments.
• Drug Discovery & Screening: Employed in high-throughput screening (HTS) platforms to identify and validate potential inhibitors of amyloid aggregation.
• Antibody Production & Characterization: Acts as an immunogen for generating specific antibodies or as a ligand for testing antibody affinity and specificity.
• Biophysical Studies: Analysis of peptide conformation, stability, and interactions using techniques like NMR, CD spectroscopy, and mass spectrometry.

Basic Information

Product Name	β-Amyloid (33-40)
CAS No.	634204-57-2
Molecular Formula	C41H62N12O12
Molecular Weight	915.0 g/mol
Synonyms	Amyloid β-Protein (33-40); Aβ (33-40); β-Amyloid Peptide (33-40); Amyloid β-Protein Fragment 33-40; H-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH; GLMVGGVV; APP (672-679)
EINECS	Contact for details

Quality Control

Every batch of β-Amyloid (33-40) is manufactured and tested under stringent quality management protocols to ensure the highest standards of purity and consistency for research applications. Our products undergo rigorous analytical testing, including reversed-phase HPLC and mass spectrometry, to confirm identity and purity. Certificates of Analysis (COA) detailing batch-specific results for purity, peptide content, and solvent residues are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to store desiccated. Allow the vial to reach room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Molecular Weight	915.0 ± 2.0 Da (by Mass Spectrometry)
Solvent Residues	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.